2-hydroxymethylglutarate dehydrogenase

From Wikipedia, the free encyclopedia

In enzymology, a 2-hydroxymethylglutarate dehydrogenase (EC 1.1.1.291) is an enzyme that catalyzes the chemical reaction

(S)-2-hydroxymethylglutarate + NAD⁺ 2-formylglutarate + NADH + H⁺

Thus, the two substrates of this enzyme are (S)-2-hydroxymethylglutarate and NAD⁺, whereas its 3 products are 2-formylglutarate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (S)-2-hydroxymethylglutarate:NAD+ oxidoreductase. This enzyme is also called HgD.

[edit] References

• IUBMB entry for 1.1.1.291
• BRENDA references for 1.1.1.291 (Recommended.)
• PubMed references for 1.1.1.291
• PubMed Central references for 1.1.1.291
• Google Scholar references for 1.1.1.291
• Alhapel A, Darley DJ, Wagener N, Eckel E, Elsner N, Pierik AJ (2006). "Molecular and functional analysis of nicotinate catabolism in Eubacterium barkeri". Proc. Natl. Acad. Sci. U. S. A. 103: 12341–6. doi:10.1073/pnas.0601635103. PMID 16894175. 

[edit] External links

• IUBMB entry for 1.1.1.291

• KEGG entry for 1.1.1.291

• BRENDA entry for 1.1.1.291

• NiceZyme view of 1.1.1.291

• EC2PDB: PDB structures for 1.1.1.291

• PRIAM entry for 1.1.1.291

• PUMA2 entry for 1.1.1.291

• IntEnz: Integrated Enzyme entry for 1.1.1.291

• MetaCyc entry for 1.1.1.291

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0043718: 2-hydroxymethylglutarate dehydrogenase

• AMIGO entry for GO code 0043718: 2-hydroxymethylglutarate dehydrogenase