2-hydroxyisoflavanone synthase

From Wikipedia, the free encyclopedia

In enzymology, a 2-hydroxyisoflavanone synthase (EC 1.14.13.86) is an enzyme that catalyzes the chemical reaction

apigenin + 2 NADPH + 2 H⁺ + O₂ 2-hydroxy-2,3-dihydrogenistein + 2 NADP⁺ + H₂O

The 4 substrates of this enzyme are apigenin, NADPH, H⁺, and O₂, whereas its 3 products are 2-hydroxy-2,3-dihydrogenistein, NADP⁺, and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of one atom o oxygen into the other donor. The systematic name of this enzyme class is apigenin,NADPH:oxygen oxidoreductase (isoflavanone-forming). This enzyme participates in isoflavonoid biosynthesis.

[edit] References

• IUBMB entry for 1.14.13.86
• BRENDA references for 1.14.13.86 (Recommended.)
• PubMed references for 1.14.13.86
• PubMed Central references for 1.14.13.86
• Google Scholar references for 1.14.13.86
• Kochs G, Grisebach H (1986). "Enzymic synthesis of isoflavones". Eur. J. Biochem. 155: 311–8. doi:10.1111/j.1432-1033.1986.tb09492.x. PMID 3956488. 
• Steele CL, Gijzen M, Qutob D, Dixon RA (1999). "Molecular characterization of the enzyme catalyzing the aryl migration reaction of isoflavonoid biosynthesis in soybean". Arch. Biochem. Biophys. 367: 146–50. doi:10.1006/abbi.1999.1238. PMID 10375412. 

[edit] External links

• IUBMB entry for 1.14.13.86

• KEGG entry for 1.14.13.86

• BRENDA entry for 1.14.13.86

• NiceZyme view of 1.14.13.86

• EC2PDB: PDB structures for 1.14.13.86

• PRIAM entry for 1.14.13.86

• PUMA2 entry for 1.14.13.86

• IntEnz: Integrated Enzyme entry for 1.14.13.86

• MetaCyc entry for 1.14.13.86

• Atomic-resolution structures of enzymes belonging to this class