2-hydroxyglutarate synthase

From Wikipedia, the free encyclopedia

In enzymology, a 2-hydroxyglutarate synthase (EC 2.3.3.11) is an enzyme that catalyzes the chemical reaction

propanoyl-CoA + H₂O + glyoxylate 2-hydroxyglutarate + CoA

The 3 substrates of this enzyme are propanoyl-CoA, H₂O, and glyoxylate, whereas its two products are 2-hydroxyglutarate and CoA.

This enzyme belongs to the family of transferases, specifically those acyltransferases that convert acyl groups into alkyl groups on transfer. The systematic name of this enzyme class is propanoyl-CoA:glyoxylate C-propanoyltransferase (thioester-hydrolysing, 2-carboxyethyl-forming). Other names in common use include 2-hydroxyglutaratic synthetase, 2-hydroxyglutaric synthetase, alpha-hydroxyglutarate synthase, hydroxyglutarate synthase, and 2-hydroxyglutarate glyoxylate-lyase (CoA-propanoylating). This enzyme participates in c5-branched dibasic acid metabolism.

[edit] References

• IUBMB entry for 2.3.3.11
• BRENDA references for 2.3.3.11 (Recommended.)
• PubMed references for 2.3.3.11
• PubMed Central references for 2.3.3.11
• Google Scholar references for 2.3.3.11
• Reeves HC and Ajl SJ (1962). "alpha-Hydroxyglutaric acid synthetase". J. Bacteriol. 84: 186–187. 

[edit] External links

The CAS registry number for this enzyme class is 9024-02-6.

• IUBMB entry for 2.3.3.11

• KEGG entry for 2.3.3.11

• BRENDA entry for 2.3.3.11

• NiceZyme view of 2.3.3.11

• EC2PDB: PDB structures for 2.3.3.11

• PRIAM entry for 2.3.3.11

• PUMA2 entry for 2.3.3.11

• IntEnz: Integrated Enzyme entry for 2.3.3.11

• MetaCyc entry for 2.3.3.11

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0019142: 2-hydroxyglutarate synthase

• AMIGO entry for GO code 0019142: 2-hydroxyglutarate synthase