2-hydroxyglutarate dehydrogenase

From Wikipedia, the free encyclopedia

In enzymology, a 2-hydroxyglutarate dehydrogenase (EC 1.1.99.2) is an enzyme that catalyzes the chemical reaction

(S)-2-hydroxyglutarate + acceptor 2-oxoglutarate + reduced acceptor

Thus, the two substrates of this enzyme are (S)-2-hydroxyglutarate and acceptor, whereas its two products are 2-oxoglutarate and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with other acceptors. The systematic name of this enzyme class is (S)-2-hydroxyglutarate:acceptor 2-oxidoreductase. Other names in common use include alpha-ketoglutarate reductase, alpha-hydroxyglutarate dehydrogenase, L-alpha-hydroxyglutarate dehydrogenase, hydroxyglutaric dehydrogenase, alpha-hydroxyglutarate oxidoreductase, L-alpha-hydroxyglutarate:NAD+ 2-oxidoreductase, alpha-hydroxyglutarate dehydrogenase (NAD+ specific), and (S)-2-hydroxyglutarate:(acceptor) 2-oxidoreductase. This enzyme participates in butanoate metabolism.

[edit] References

• IUBMB entry for 1.1.99.2
• BRENDA references for 1.1.99.2 (Recommended.)
• PubMed references for 1.1.99.2
• PubMed Central references for 1.1.99.2
• Google Scholar references for 1.1.99.2
• Weil-Malherbe H (1937). "The oxidation of l(-)alpha-hydroxyglutaric acid in animal tissues". Biochem. J. 31: 2080–2094. 

[edit] External links

The CAS registry number for this enzyme class is 9028-80-2.

• IUBMB entry for 1.1.99.2

• KEGG entry for 1.1.99.2

• BRENDA entry for 1.1.99.2

• NiceZyme view of 1.1.99.2

• EC2PDB: PDB structures for 1.1.99.2

• PRIAM entry for 1.1.99.2

• PUMA2 entry for 1.1.99.2

• IntEnz: Integrated Enzyme entry for 1.1.99.2

• MetaCyc entry for 1.1.99.2

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047545: 2-hydroxyglutarate dehydrogenase

• AMIGO entry for GO code 0047545: 2-hydroxyglutarate dehydrogenase