2-hydroxyacylsphingosine 1-beta-galactosyltransferase

From Wikipedia, the free encyclopedia

In enzymology, a 2-hydroxyacylsphingosine 1-beta-galactosyltransferase (EC 2.4.1.45) is an enzyme that catalyzes the chemical reaction

UDP-galactose + 2-(2-hydroxyacyl)sphingosine $\rightleftharpoons$ UDP + 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine

Thus, the two substrates of this enzyme are UDP-galactose and 2-(2-hydroxyacyl)sphingosine, whereas its two products are UDP and 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-galactose:2-(2-hydroxyacyl)sphingosine 1-beta-D-galactosyl-transferase. Other names in common use include uridine diphosphogalactose-2-hydroxyacylsphingosine, galactosyltransferase, UDPgalactose-2-hydroxyacylsphingosine galactosyltransferase, UDP-galactose:ceramide galactosyltransferase, and UDP-galactose:2-2-hydroxyacylsphingosine galactosyltransferase.

[edit] References

IUBMB entry for 2.4.1.45
BRENDA references for 2.4.1.45 (Recommended.)
PubMed references for 2.4.1.45
PubMed Central references for 2.4.1.45
Google Scholar references for 2.4.1.45
Basu S, Schultz AM, Basu M, Roseman S (1971). "Enzymatic synthesis of galactocerebroside by a galactosyltransferase from embryonic chicken brain". J. Biol. Chem. 246: 4272–9. PMID 5090043.
Morell P, Radin NS (1969). "Synthesis of cerebroside by brain from uridine diphosphate galactose and ceramide containing hydroxy fatty acid". Biochemistry. 8: 506–12. doi:10.1021/bi00830a008. PMID 5793706.