2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate reductase

From Wikipedia, the free encyclopedia

In enzymology, a 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate reductase (EC 1.3.1.40) is an enzyme that catalyzes the chemical reaction

2,6-dioxo-6-phenylhexanoate + NADP⁺ 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + NADPH + H⁺

Thus, the two substrates of this enzyme are 2,6-dioxo-6-phenylhexanoate and NADP⁺, whereas its 3 products are 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2,6-dioxo-6-phenylhexanoate:NADP+ Delta2-oxidoreductase. Other names in common use include 2-hydroxy-6-oxo-phenylhexa-2,4-dienoate (reduced nicotinamide, and adenine dinucleotide phosphate) reductase.

[edit] References

• IUBMB entry for 1.3.1.40
• BRENDA references for 1.3.1.40 (Recommended.)
• PubMed references for 1.3.1.40
• PubMed Central references for 1.3.1.40
• Google Scholar references for 1.3.1.40
• Omori T, Ishigooka H and Minoda Y (1986). "Purification and some properties of 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid(HOPDA) reducing enzyme from Pseudomonas cruciviae S93B1 involved in the degradation of biphenyl". Agric. Biol. Chem. 50: 1513–1518. 

[edit] External links

The CAS registry number for this enzyme class is 104645-83-2.

• IUBMB entry for 1.3.1.40

• KEGG entry for 1.3.1.40

• BRENDA entry for 1.3.1.40

• NiceZyme view of 1.3.1.40

• EC2PDB: PDB structures for 1.3.1.40

• PRIAM entry for 1.3.1.40

• PUMA2 entry for 1.3.1.40

• IntEnz: Integrated Enzyme entry for 1.3.1.40

• MetaCyc entry for 1.3.1.40

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047118: 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate reductase

• AMIGO entry for GO code 0047118: 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate reductase