2-hydroxy-3-oxopropionate reductase

From Wikipedia, the free encyclopedia

In enzymology, a 2-hydroxy-3-oxopropionate reductase (EC 1.1.1.60) is an enzyme that catalyzes the chemical reaction

(R)-glycerate + NAD(P)+ 2-hydroxy-3-oxopropanoate + NAD(P)H + H⁺

The 3 substrates of this enzyme are (R)-glycerate, NAD⁺, and NADP⁺, whereas its 4 products are 2-hydroxy-3-oxopropanoate, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-glycerate:NAD(P)+ oxidoreductase. This enzyme is also called tartronate semialdehyde reductase. This enzyme participates in glyoxylate and dicarboxylate metabolism.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1YB4.

[edit] References

• IUBMB entry for 1.1.1.60
• BRENDA references for 1.1.1.60 (Recommended.)
• PubMed references for 1.1.1.60
• PubMed Central references for 1.1.1.60
• Google Scholar references for 1.1.1.60
• GOTTO AM, KORNBERG HL (1961). "The metabolism of C2 compounds in micro-organisms. 7. Preparation and properties of crystalline tartronic semialdehyde reductase". Biochem. J. 81: 273–84. PMID 13900766. 

[edit] External links

The CAS registry number for this enzyme class is 9028-68-6.

• IUBMB entry for 1.1.1.60

• KEGG entry for 1.1.1.60

• BRENDA entry for 1.1.1.60

• NiceZyme view of 1.1.1.60

• EC2PDB: PDB structures for 1.1.1.60

• PRIAM entry for 1.1.1.60

• PUMA2 entry for 1.1.1.60

• IntEnz: Integrated Enzyme entry for 1.1.1.60

• MetaCyc entry for 1.1.1.60

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0008679: 2-hydroxy-3-oxopropionate reductase

• AMIGO entry for GO code 0008679: 2-hydroxy-3-oxopropionate reductase