2-hydroxy-3-oxoadipate synthase

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In enzymology, a 2-hydroxy-3-oxoadipate synthase (EC 2.2.1.5) is an enzyme that catalyzes the chemical reaction

2-oxoglutarate + glyoxylate $\rightleftharpoons$ 2-hydroxy-3-oxoadipate + CO₂

Thus, the two substrates of this enzyme are 2-oxoglutarate and glyoxylate, whereas its two products are 2-hydroxy-3-oxoadipate and CO₂.

This enzyme belongs to the family of transferases, specifically those transferring aldehyde or ketonic groups (transaldolases and transketolases, respectively). The systematic name of this enzyme class is '. Other names in common use include 2-hydroxy-3-oxoadipate glyoxylate-lyase (carboxylating)', alpha-ketoglutaric-glyoxylic carboligase, and oxoglutarate: glyoxylate carboligase. This enzyme participates in glyoxylate and dicarboxylate metabolism. It employs one cofactor, thiamin diphosphate.

[edit] References

IUBMB entry for 2.2.1.5
BRENDA references for 2.2.1.5 (Recommended.)
PubMed references for 2.2.1.5
PubMed Central references for 2.2.1.5
Google Scholar references for 2.2.1.5
Schlossberg MA, Bloom RJ, Richert DA, Westerfeld WW (1970). "Carboligase activity of alpha-ketoglutarate dehydrogenase". Biochemistry. 9: 1148–53. PMID 5418712.
Schlossberg MA, Richert DA, Bloom RJ, Westerfeld WW (1968). "Isolation and identification of 5-hydroxy-4-ketovaleric acid as a product of alpha-ketoglutarate: glyoxylate carboligase". Biochemistry. 7: 333–7. PMID 4320439.
Stewart PR and Quayle JR (1967). "The synergistic decarboxylation of glyoxalate and 2-oxoglutarate by an enzyme system from pig-liver mitochondria". Biochem. J. 102: 885–897.