2-deoxy-D-gluconate 3-dehydrogenase

From Wikipedia, the free encyclopedia

In enzymology, a 2-deoxy-D-gluconate 3-dehydrogenase (EC 1.1.1.125) is an enzyme that catalyzes the chemical reaction

2-deoxy-D-gluconate + NAD⁺ 3-dehydro-2-deoxy-D-gluconate + NADH + H⁺

Thus, the two substrates of this enzyme are 2-deoxy-D-gluconate and NAD⁺, whereas its 3 products are 3-dehydro-2-deoxy-D-gluconate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2-deoxy-D-gluconate:NAD+ 3-oxidoreductase. This enzyme is also called 2-deoxygluconate dehydrogenase. This enzyme participates in pentose and glucuronate interconversions.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1X1E.

[edit] References

• IUBMB entry for 1.1.1.125
• BRENDA references for 1.1.1.125 (Recommended.)
• PubMed references for 1.1.1.125
• PubMed Central references for 1.1.1.125
• Google Scholar references for 1.1.1.125
• Eichhorn MM and Cynkin MA (1965). "Microbial metabolism of 2-deoxyglucose; 2-deoxyglucose acid dehydrogenase". Biochemistry 4: 159–165. doi:10.1021/bi00877a024. 

[edit] External links

The CAS registry number for this enzyme class is 37250-54-7.

• IUBMB entry for 1.1.1.125

• KEGG entry for 1.1.1.125

• BRENDA entry for 1.1.1.125

• NiceZyme view of 1.1.1.125

• EC2PDB: PDB structures for 1.1.1.125

• PRIAM entry for 1.1.1.125

• PUMA2 entry for 1.1.1.125

• IntEnz: Integrated Enzyme entry for 1.1.1.125

• MetaCyc entry for 1.1.1.125

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0008678: 2-deoxy-D-gluconate 3-dehydrogenase

• AMIGO entry for GO code 0008678: 2-deoxy-D-gluconate 3-dehydrogenase