2-dehydropantoate aldolase

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In enzymology, a 2-dehydropantoate aldolase (EC 4.1.2.12) is an enzyme that catalyzes the chemical reaction

2-dehydropantoate 3-methyl-2-oxobutanoate + formaldehyde

Hence, this enzyme has one substrate, 2-dehydropantoate, and two products, 3-methyl-2-oxobutanoate and formaldehyde.

This enzyme belongs to the family of lyases, specifically the aldehyde-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 2-dehydropantoate formaldehyde-lyase (3-methyl-2-oxobutanoate-forming). Other names in common use include ketopantoaldolase, and 2-dehydropantoate formaldehyde-lyase.

[edit] References

• IUBMB entry for 4.1.2.12
• BRENDA references for 4.1.2.12 (Recommended.)
• PubMed references for 4.1.2.12
• PubMed Central references for 4.1.2.12
• Google Scholar references for 4.1.2.12
• McIntosh EN, Purko M and Wood WA (1957). "Ketopantoate formation by a hydroxymethylation enzyme from Escherichia coli". J. Biol. Chem. 228: 499–510. 

[edit] External links

The CAS registry number for this enzyme class is 9024-51-5.

• IUBMB entry for 4.1.2.12

• KEGG entry for 4.1.2.12

• BRENDA entry for 4.1.2.12

• NiceZyme view of 4.1.2.12

• EC2PDB: PDB structures for 4.1.2.12

• PRIAM entry for 4.1.2.12

• PUMA2 entry for 4.1.2.12

• IntEnz: Integrated Enzyme entry for 4.1.2.12

• MetaCyc entry for 4.1.2.12

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050013: 2-dehydropantoate aldolase

• AMIGO entry for GO code 0050013: 2-dehydropantoate aldolase