2-dehydropantoate 2-reductase

From Wikipedia, the free encyclopedia

In enzymology, a 2-dehydropantoate 2-reductase (EC 1.1.1.169) is an enzyme that catalyzes the chemical reaction

(R)-pantoate + NADP⁺ $\rightleftharpoons$ 2-dehydropantoate + NADPH + H⁺

Thus, the two substrates of this enzyme are (R)-pantoate and NADP⁺, whereas its 3 products are 2-dehydropantoate, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-pantoate:NADP+ 2-oxidoreductase. Other names in common use include 2-oxopantoate reductase, 2-ketopantoate reductase, 2-ketopantoic acid reductase, ketopantoate reductase, and ketopantoic acid reductase. This enzyme participates in pantothenate and coa biosynthesis.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 1KS9, 1YJQ, 1YON, 2EW2, and 2OFP.

[edit] References

IUBMB entry for 1.1.1.169
BRENDA references for 1.1.1.169 (Recommended.)
PubMed references for 1.1.1.169
PubMed Central references for 1.1.1.169
Google Scholar references for 1.1.1.169
King HL, Jr and Wilken DR (1972). "Ketopantoyl lactone and ketopantoic acid reductases Characterization of the reactions and purification of two forms of ketopantoyl lactone reductase". J. Biol. Chem. 247: 4689–4695.