2-dehydro-3-deoxygluconokinase
From Wikipedia, the free encyclopedia
In enzymology, a 2-dehydro-3-deoxygluconokinase (EC 2.7.1.45) is an enzyme that catalyzes the chemical reaction
- ATP + 2-dehydro-3-deoxy-D-gluconate
ADP + 6-phospho-2-dehydro-3-deoxy-D-gluconate
Thus, the two substrates of this enzyme are ATP and 2-dehydro-3-deoxy-D-gluconate, whereas its two products are ADP and 6-phospho-2-dehydro-3-deoxy-D-gluconate.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:2-dehydro-3-deoxy-D-gluconate 6-phosphotransferase. Other names in common use include 2-keto-3-deoxygluconokinase, 2-keto-3-deoxy-D-gluconic acid kinase, 2-keto-3-deoxygluconokinase (phosphorylating), 2-keto-3-deoxygluconate kinase, and ketodeoxygluconokinase. This enzyme participates in pentose phosphate pathway and pentose and glucuronate interconversions.
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[edit] Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1WYE.
[edit] References
- IUBMB entry for 2.7.1.45
- BRENDA references for 2.7.1.45 (Recommended.)
- PubMed references for 2.7.1.45
- PubMed Central references for 2.7.1.45
- Google Scholar references for 2.7.1.45
- CYNKIN MA, ASHWELL G (1960). "Uronic acid metabolism in bacteria. IV. Purification and properties of 2-keto-3-deoxy-D-gluconokinase in Escherichia coli". J. Biol. Chem. 235: 1576–9. PMID 13813474.
[edit] External links
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- The CAS registry number for this enzyme class is 9026-54-4.
[edit] Gene Ontology (GO) codes
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