2-dehydro-3-deoxy-L-pentonate aldolase

From Wikipedia, the free encyclopedia

In enzymology, a 2-dehydro-3-deoxy-L-pentonate aldolase (EC 4.1.2.18) is an enzyme that catalyzes the chemical reaction

2-dehydro-3-deoxy-L-pentonate pyruvate + glycolaldehyde

Hence, this enzyme has one substrate, 2-dehydro-3-deoxy-L-pentonate, and two products, pyruvate and glycolaldehyde.

This enzyme belongs to the family of lyases, specifically the aldehyde-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 2-dehydro-3-deoxy-L-pentonate glycolaldehyde-lyase (pyruvate-forming). Other names in common use include 2-keto-3-deoxy-L-pentonate aldolase, 2-keto-3-deoxy-L-arabonate aldolase, 2-keto-3-deoxy-D-xylonate aldolase, 3-deoxy-D-pentulosonic acid aldolase, and 2-dehydro-3-deoxy-L-pentonate glycolaldehyde-lyase. This enzyme participates in fructose and mannose metabolism.

[edit] References

• IUBMB entry for 4.1.2.18
• BRENDA references for 4.1.2.18 (Recommended.)
• PubMed references for 4.1.2.18
• PubMed Central references for 4.1.2.18
• Google Scholar references for 4.1.2.18
• Dahms AS, Anderson RL (1969). "2-keto-3-deoxyl-L-arabonate aldolase and its role in a new pathway of L-arabinose degradation". Biochem. Biophys. Res. Commun. 36: 809–14. PMID 5808295. 

[edit] External links

The CAS registry number for this enzyme class is 9076-49-7.

• IUBMB entry for 4.1.2.18

• KEGG entry for 4.1.2.18

• BRENDA entry for 4.1.2.18

• NiceZyme view of 4.1.2.18

• EC2PDB: PDB structures for 4.1.2.18

• PRIAM entry for 4.1.2.18

• PUMA2 entry for 4.1.2.18

• IntEnz: Integrated Enzyme entry for 4.1.2.18

• MetaCyc entry for 4.1.2.18

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047438: 2-dehydro-3-deoxy-L-pentonate aldolase

• AMIGO entry for GO code 0047438: 2-dehydro-3-deoxy-L-pentonate aldolase