2-dehydro-3-deoxy-D-pentonate aldolase

From Wikipedia, the free encyclopedia

In enzymology, a 2-dehydro-3-deoxy-D-pentonate aldolase (EC 4.1.2.28) is an enzyme that catalyzes the chemical reaction

2-dehydro-3-deoxy-D-pentonate pyruvate + glycolaldehyde

Hence, this enzyme has one substrate, 2-dehydro-3-deoxy-D-pentonate, and two products, pyruvate and glycolaldehyde.

This enzyme belongs to the family of lyases, specifically the aldehyde-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 2-dehydro-3-deoxy-D-pentonate glycolaldehyde-lyase (pyruvate-forming). Other names in common use include 2-keto-3-deoxy-D-pentonate aldolase, 3-deoxy-D-pentulosonic acid aldolase, and 2-dehydro-3-deoxy-D-pentonate glycolaldehyde-lyase. This enzyme participates in pentose and glucuronate interconversions.

[edit] References

• IUBMB entry for 4.1.2.28
• BRENDA references for 4.1.2.28 (Recommended.)
• PubMed references for 4.1.2.28
• PubMed Central references for 4.1.2.28
• Google Scholar references for 4.1.2.28
• Dahms AS (1974). "3-Deoxy-D-pentulosonic acid aldolase and its role in a new pathway of D-xylose degradation". Biochem. Biophys. Res. Commun. 60: 1433–9. PMID 4423285. 
• Dahms AS, Donald A (1982). "2-Keto-3-deoxy-d-xylonate aldolase (3-deoxy-d-pentulosonic acid aldolase)". Methods. Enzymol. 90 Pt E: 269–72. PMID 7154955. 

[edit] External links

The CAS registry number for this enzyme class is 55326-36-8.

• IUBMB entry for 4.1.2.28

• KEGG entry for 4.1.2.28

• BRENDA entry for 4.1.2.28

• NiceZyme view of 4.1.2.28

• EC2PDB: PDB structures for 4.1.2.28

• PRIAM entry for 4.1.2.28

• PUMA2 entry for 4.1.2.28

• IntEnz: Integrated Enzyme entry for 4.1.2.28

• MetaCyc entry for 4.1.2.28

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047440: 2-dehydro-3-deoxy-D-pentonate aldolase

• AMIGO entry for GO code 0047440: 2-dehydro-3-deoxy-D-pentonate aldolase