2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase

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In enzymology, a 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase (EC 1.1.1.127) is an enzyme that catalyzes the chemical reaction

2-dehydro-3-deoxy-D-gluconate + NAD⁺ $\rightleftharpoons$ (4S)-4,6-dihydroxy-2,5-dioxohexanoate + NADH + H⁺

Thus, the two substrates of this enzyme are 2-dehydro-3-deoxy-D-gluconate and NAD⁺, whereas its 3 products are (4S)-4,6-dihydroxy-2,5-dioxohexanoate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2-dehydro-3-deoxy-D-gluconate:NAD+ 5-oxidoreductase. Other names in common use include 2-keto-3-deoxygluconate 5-dehydrogenase, 2-keto-3-deoxy-D-gluconate dehydrogenase, 2-keto-3-deoxygluconate (nicotinamide adenine dinucleotide, (phosphate)) dehydrogenase, 2-keto-3-deoxy-D-gluconate (3-deoxy-D-glycero-2,5-hexodiulosonic, and acid) dehydrogenase. This enzyme participates in pentose and glucuronate interconversions.

[edit] References

IUBMB entry for 1.1.1.127
BRENDA references for 1.1.1.127 (Recommended.)
PubMed references for 1.1.1.127
PubMed Central references for 1.1.1.127
Google Scholar references for 1.1.1.127
Condemine G, Hugouvieux-Cotte-Pattat N and Robert-Baudouy J (1984). "An enzyme in the pectolytic pathway of Erwinia chrysanthemi: 3-keto-3-deoxygluconate oxidoreductase". J. Gen. Microbiol. 130: 2839–2844.
Preiss J and Ashwell G (1963). "Polygalacturonic acid metabolism in bacteria. II. Formation and metabolism of 3-deoxy-D-glycero-2,5-hexodiulosonic acid". J. Biol. Chem. 238: 1577–1583.