2-coumarate reductase

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In enzymology, a 2-coumarate reductase (EC 1.3.1.11) is an enzyme that catalyzes the chemical reaction

3-(2-hydroxyphenyl)propanoate + NAD⁺ 2-coumarate + NADH + H⁺

Thus, the two substrates of this enzyme are 3-(2-hydroxyphenyl)propanoate and NAD⁺, whereas its 3 products are 2-coumarate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 3-(2-hydroxyphenyl)propanoate:NAD+ oxidoreductase. This enzyme is also called melilotate dehydrogenase. This enzyme participates in phenylalanine metabolism.

[edit] References

• IUBMB entry for 1.3.1.11
• BRENDA references for 1.3.1.11 (Recommended.)
• PubMed references for 1.3.1.11
• PubMed Central references for 1.3.1.11
• Google Scholar references for 1.3.1.11
• Levy CC and Weinstein GD (1964). "The metabolism of coumarin by a microorganism. II. The reduction of o-coumaric acid to melilotic acid". Biochemistry 3: 1944–1947. doi:10.1021/bi00900a027. 

[edit] External links

The CAS registry number for this enzyme class is 37251-10-8.

• IUBMB entry for 1.3.1.11

• KEGG entry for 1.3.1.11

• BRENDA entry for 1.3.1.11

• NiceZyme view of 1.3.1.11

• EC2PDB: PDB structures for 1.3.1.11

• PRIAM entry for 1.3.1.11

• PUMA2 entry for 1.3.1.11

• IntEnz: Integrated Enzyme entry for 1.3.1.11

• MetaCyc entry for 1.3.1.11

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047788: 2-coumarate reductase

• AMIGO entry for GO code 0047788: 2-coumarate reductase