2-aminomuconate deaminase

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In enzymology, a 2-aminomuconate deaminase (EC 3.5.99.5) is an enzyme that catalyzes the chemical reaction

2-aminomuconate + H₂O $\rightleftharpoons$ 4-oxalocrotonate + NH₃

Thus, the two substrates of this enzyme are 2-aminomuconate and H₂O, whereas its two products are 4-oxalocrotonate and NH₃.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in compounds that have not been otherwise categorized within EC number 3.5. The systematic name of this enzyme class is 2-aminomuconate aminohydrolase. This enzyme participates in tryptophan metabolism.

[edit] References

IUBMB entry for 3.5.99.5
BRENDA references for 3.5.99.5 (Recommended.)
PubMed references for 3.5.99.5
PubMed Central references for 3.5.99.5
Google Scholar references for 3.5.99.5
He Z, Spain JC (1998). "A novel 2-aminomuconate deaminase in the nitrobenzene degradation pathway of Pseudomonas pseudoalcaligenes JS45". J. Bacteriol. 180: 2502–6. PMID 9573204.
He Z, Spain JC (1997). "Studies of the catabolic pathway of degradation of nitrobenzene by Pseudomonas pseudoalcaligenes JS45: removal of the amino group from 2-aminomuconic semialdehyde". Appl. Environ. Microbiol. 63: 4839–43. PMID 9471964.