2-aminobenzenesulfonate 2,3-dioxygenase

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In enzymology, a 2-aminobenzenesulfonate 2,3-dioxygenase (EC 1.14.12.14) is an enzyme that catalyzes the chemical reaction

2-aminobenzenesulfonate + NADH + H⁺ + O₂ $\rightleftharpoons$ 2,3-dihydroxybenzenesulfonate + NH₃ + NAD⁺

The 4 substrates of this enzyme are 2-aminobenzenesulfonate, NADH, H⁺, and O₂, whereas its 3 products are 2,3-dihydroxybenzenesulfonate, NH₃, and NAD⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of two atoms o oxygen into the other donor. The systematic name of this enzyme class is 2-aminobenzenesulfonate,NADH:oxygen oxidoreductase (2,3-hydroxylating, ammonia-forming). This enzyme is also called 2-aminosulfobenzene 2,3-dioxygenase. This enzyme participates in benzoate degradation via hydroxylation.

[edit] References

IUBMB entry for 1.14.12.14
BRENDA references for 1.14.12.14 (Recommended.)
PubMed references for 1.14.12.14
PubMed Central references for 1.14.12.14
Google Scholar references for 1.14.12.14
CL, Mason JR, Leisinger T, Cook AM (Pt 2). "Oxygenation and spontaneous deamination of 2-aminobenzenesulphonic acid in Alcaligenes sp. strain O-1 with subsequent meta ring cleavage and spontaneous desulphonation to 2-hydroxymuconic acid". Biochem. J. 300: 429–36. PMID 8002948.
Junker F, Leisinger T, Cook AM (Pt 7). "3-Sulphocatechol 2,3-dioxygenase and other dioxygenases (EC 1.13.11.2 and EC 1.14.12.-) in the degradative pathways of 2-aminobenzenesulphonic, benzenesulphonic and 4-toluenesulphonic acids in Alcaligenes sp. strain O-1". Microbiology. 140: 1713–22. PMID 8075807.