2-aminoadipate transaminase
From Wikipedia, the free encyclopedia
In enzymology, a 2-aminoadipate transaminase (EC 2.6.1.39) is an enzyme that catalyzes the chemical reaction
- L-2-aminoadipate + 2-oxoglutarate
2-oxoadipate + L-glutamate
Thus, the two substrates of this enzyme are L-2-aminoadipate and 2-oxoglutarate, whereas its two products are 2-oxoadipate and L-glutamate.
This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is L-2-aminoadipate:2-oxoglutarate aminotransferase. Other names in common use include alpha-aminoadipate aminotransferase, 2-aminoadipate aminotransferase, 2-aminoadipic aminotransferase, glutamic-ketoadipic transaminase, and glutamate-alpha-ketoadipate transaminase. This enzyme participates in lysine biosynthesis and lysine degradation. It employs one cofactor, pyridoxal phosphate.
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[edit] Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2DTV.
[edit] References
- IUBMB entry for 2.6.1.39
- BRENDA references for 2.6.1.39 (Recommended.)
- PubMed references for 2.6.1.39
- PubMed Central references for 2.6.1.39
- Google Scholar references for 2.6.1.39
- Matsuda M, Ogur M (1969). "Separation and specificity of the yeast glutamate-alpha-ketoadipate transaminase". J. Biol. Chem. 244: 3352–8. PMID 5792664.
[edit] External links
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- The CAS registry number for this enzyme class is 9033-00-5.
[edit] Gene Ontology (GO) codes
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