2-acylglycerol-3-phosphate O-acyltransferase

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In enzymology, a 2-acylglycerol-3-phosphate O-acyltransferase (EC 2.3.1.52) is an enzyme that catalyzes the chemical reaction

acyl-CoA + 2-acyl-sn-glycerol 3-phosphate CoA + 1,2-diacyl-sn-glycerol 3-phosphate

Thus, the two substrates of this enzyme are acyl-CoA and 2-acyl-sn-glycerol 3-phosphate, whereas its two products are CoA and 1,2-diacyl-sn-glycerol 3-phosphate.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl-CoA:2-acyl-sn-glycerol 3-phosphate O-acyltransferase. This enzyme is also called 2-acylglycerophosphate acyltransferase. This enzyme participates in glycerophospholipid metabolism.

[edit] References

• IUBMB entry for 2.3.1.52
• BRENDA references for 2.3.1.52 (Recommended.)
• PubMed references for 2.3.1.52
• PubMed Central references for 2.3.1.52
• Google Scholar references for 2.3.1.52
• Yamashita S, Hosaka K, Numa S (1973). "Acyl-donor specificities of partially purified 1-acylglycerophosphate acyltransferase, 2-acylglycerophosphate acyltransferase and 1-acylglycerophosphorylcholine acyltransferase from rat-liver microsomes". Eur. J. Biochem. 38: 25–31. PMID 4774123. 

[edit] External links

The CAS registry number for this enzyme class is 51901-17-8.

• IUBMB entry for 2.3.1.52

• KEGG entry for 2.3.1.52

• BRENDA entry for 2.3.1.52

• NiceZyme view of 2.3.1.52

• EC2PDB: PDB structures for 2.3.1.52

• PRIAM entry for 2.3.1.52

• PUMA2 entry for 2.3.1.52

• IntEnz: Integrated Enzyme entry for 2.3.1.52

• MetaCyc entry for 2.3.1.52

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047144: 2-acylglycerol-3-phosphate O-acyltransferase

• AMIGO entry for GO code 0047144: 2-acylglycerol-3-phosphate O-acyltransferase