2-acetolactate mutase

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In enzymology, a 2-acetolactate mutase (EC 5.4.99.3) is an enzyme that catalyzes the chemical reaction

2-acetolactate 3-hydroxy-3-methyl-2-oxobutanoate

Hence, this enzyme has one substrate, 2-acetolactate, and one product, 3-hydroxy-3-methyl-2-oxobutanoate.

This enzyme belongs to the family of isomerases, specifically those intramolecular transferases transferring other groups. The systematic name of this enzyme class is 2-acetolactate methylmutase. Other names in common use include acetolactate mutase, and acetohydroxy acid isomerase. This enzyme participates in valine, leucine and isoleucine biosynthesis. It employs one cofactor, ascorbate.

[edit] References

• IUBMB entry for 5.4.99.3
• BRENDA references for 5.4.99.3 (Recommended.)
• PubMed references for 5.4.99.3
• PubMed Central references for 5.4.99.3
• Google Scholar references for 5.4.99.3
• Allaudeen HS, Ramakrishnan T (1968). "Biosynthesis of isoleucine and valine in Mycobacterium tuberculosis H37 Rv". Arch. Biochem. Biophys. 125: 199–209. doi:10.1016/0003-9861(68)90655-3. PMID 4384955. 

[edit] External links

The CAS registry number for this enzyme class is 37318-52-8.

• IUBMB entry for 5.4.99.3

• KEGG entry for 5.4.99.3

• BRENDA entry for 5.4.99.3

• NiceZyme view of 5.4.99.3

• EC2PDB: PDB structures for 5.4.99.3

• PRIAM entry for 5.4.99.3

• PUMA2 entry for 5.4.99.3

• IntEnz: Integrated Enzyme entry for 5.4.99.3

• MetaCyc entry for 5.4.99.3

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047534: 2-acetolactate mutase

• AMIGO entry for GO code 0047534: 2-acetolactate mutase