2-Aminoethoxydiphenyl borate

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2-Aminoethoxydiphenyl borate
IUPAC name	2-Diphenylboranyloxyethanamine
Other names	2-Aminoethyl diphenyl borate
Abbreviations	2-APB
Identifiers
CAS number	[524-95-8]
PubChem	1598
SMILES	B(C1=CC=CC=C1)(C2=CC=CC=C2)OCCN
Properties
Molecular formula	C14H16BNO
Molar mass	225.09 g mol-1
Hazards
S-phrases	S22 S24/25
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references

2-Aminoethoxydiphenyl borate (2-APB) is a chemical that acts to inhibit both IP₃ receptors^[1] and TRP channels (although it activates TRPV1, TRPV2, & TRPV3 at higher concentrations).^[2][3] In research it is used to manipulate intracellular release of calcium ions (Ca²⁺) and modify TRP channel activity, although there its lack of specific effects make it less than ideal under some circumstances. Additionally, there is evidence that 2-APB acts directly to inhibit gap junctions comprised of connexin26 or connexin32.^[4]

Also note that many manufacturers provide descriptions of known pharmacologic activity for their products (i.e. Tocris or Sigma-Aldrich)

[edit] References

1. ^ Diver JM, Sage SO, Rosado JA (2001). The inositol trisphosphate receptor antagonist 2-aminoethoxydiphenylborate (2-APB) blocks Ca2+ entry channels in human platelets: cautions for its use in studying Ca2+ influx. Cell Calcium, 30(5), 323-329.
2. ^ Xu SZ, Zeng F, Boulay G, Grimm C, Harteneck C, Beech DJ (2005). Block of TRPC5 channels by 2-aminoethoxydiphenyl borate: a differential, extracellular and voltage-dependent effect. British Journal of Pharmacology, 145(4), 320-328.
3. ^ Bootman, MD, Collins, TJ, Makenzie, L, Roderick, HL, Berridge, MJ, & Peppiatt, CM (2002). 2-Aminoethoxydiphenyl borate (2-APB) is a reliable blocker of store-operated Ca²⁺ entry but an inconsistent inhibitor of InsP3-induced Ca²⁺ release. The FASEB Journal, 16(10), 1145-1150.
4. ^ Tao, L, & Harris, AL (2007). 2-aminoethoxydiphenyl borate directly inhibits channels composed of connexin26 and/or connexin32. Molecular Pharmacology, 71(2), 570-579.