2-(S)-hydroxypropyl-CoM dehydrogenase

From Wikipedia, the free encyclopedia

In enzymology, a 2-(S)-hydroxypropyl-CoM dehydrogenase (EC 1.1.1.269) is an enzyme that catalyzes the chemical reaction

2-(S)-hydroxypropyl-CoM + NAD⁺ 2-oxopropyl-CoM + NADH + H⁺

Thus, the two substrates of this enzyme are 2-(S)-hydroxypropyl-CoM and NAD⁺, whereas its 3 products are 2-oxopropyl-CoM, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2-[2-(S)-hydroxypropylthio]ethanesulfonate:NAD+ oxidoreductase. This enzyme is also called 2-(2-(S)-hydroxypropylthio)ethanesulfonate dehydrogenase.

[edit] References

• IUBMB entry for 1.1.1.269
• BRENDA references for 1.1.1.269 (Recommended.)
• PubMed references for 1.1.1.269
• PubMed Central references for 1.1.1.269
• Google Scholar references for 1.1.1.269
• Allen JR, Clark DD, Krum JG, Ensign SA (1999). "A role for coenzyme M (2-mercaptoethanesulfonic acid) in a bacterial pathway of aliphatic epoxide carboxylation". Proc. Natl. Acad. Sci. U. S. A. 96: 8432–7. doi:10.1073/pnas.96.15.8432. PMID 10411892. 

[edit] External links

• IUBMB entry for 1.1.1.269

• KEGG entry for 1.1.1.269

• BRENDA entry for 1.1.1.269

• NiceZyme view of 1.1.1.269

• EC2PDB: PDB structures for 1.1.1.269

• PRIAM entry for 1.1.1.269

• PUMA2 entry for 1.1.1.269

• IntEnz: Integrated Enzyme entry for 1.1.1.269

• MetaCyc entry for 1.1.1.269

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050575: 2-(S)-hydroxypropyl-CoM dehydrogenase

• AMIGO entry for GO code 0050575: 2-(S)-hydroxypropyl-CoM dehydrogenase