2-(R)-hydroxypropyl-CoM dehydrogenase

From Wikipedia, the free encyclopedia

In enzymology, a 2-(R)-hydroxypropyl-CoM dehydrogenase (EC 1.1.1.268) is an enzyme that catalyzes the chemical reaction

2-(R)-hydroxypropyl-CoM + NAD⁺ 2-oxopropyl-CoM + NADH + H⁺

Thus, the two substrates of this enzyme are 2-(R)-hydroxypropyl-CoM and NAD⁺, whereas its 3 products are 2-oxopropyl-CoM, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2-[2-(R)-hydroxypropylthio]ethanesulfonate:NAD+ oxidoreductase. This enzyme is also called 2-(2-(R)-hydroxypropylthio)ethanesulfonate dehydrogenase.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2CFC.

[edit] References

• IUBMB entry for 1.1.1.268
• BRENDA references for 1.1.1.268 (Recommended.)
• PubMed references for 1.1.1.268
• PubMed Central references for 1.1.1.268
• Google Scholar references for 1.1.1.268
• Allen JR, Clark DD, Krum JG, Ensign SA (1999). "A role for coenzyme M (2-mercaptoethanesulfonic acid) in a bacterial pathway of aliphatic epoxide carboxylation". Proc. Natl. Acad. Sci. U. S. A. 96: 8432–7. doi:10.1073/pnas.96.15.8432. PMID 10411892. 

[edit] External links

• IUBMB entry for 1.1.1.268

• KEGG entry for 1.1.1.268

• BRENDA entry for 1.1.1.268

• NiceZyme view of 1.1.1.268

• EC2PDB: PDB structures for 1.1.1.268

• PRIAM entry for 1.1.1.268

• PUMA2 entry for 1.1.1.268

• IntEnz: Integrated Enzyme entry for 1.1.1.268

• MetaCyc entry for 1.1.1.268

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050574: 2-(R)-hydroxypropyl-CoM dehydrogenase

• AMIGO entry for GO code 0050574: 2-(R)-hydroxypropyl-CoM dehydrogenase