2β-Propanoyl-3β-(4-tolyl)-tropane

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2β-Propanoyl-3β-(4-tolyl)-tropane
Systematic (IUPAC) name
2β-Propanoyl-3β-(4-tolyl)-tropane
Identifiers
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Chemical data
Formula C18H25NO 
Mol. mass 271.396
Pharmacokinetic data
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2β-Propanoyl-3β-(4-tolyl)-tropane also known as WF-11 or PTT is a cocaine analogue 20 times more potent than cocaine at binding to the dopamine transporter with increased selectivity for the norepinephrine transporters. It also shows marked increase in metabolic stability. In contrast to the findings of cocaine effects, WF-11 has been shown to produce a uniform downregulation of TH protein and activity gene expression with a regimen of use. [1]

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[edit] References

  1. ^ Willard M. Freeman, George J. Yohrling, James B. Daunais, Lynda Gioia, Stephanie L. Hart, Linda J. Porrino, Huw M. L. Davies and Kent E. Vran (2000). "ScienceDirect - Drug and Alcohol Dependence : A cocaine analog, 2β-propanoyl-3β-(4-tolyl)-tropane (PTT), reduces tyrosine hydroxylase in the mesolimbic dopamine pathway". Drug and Alcohol Dependence 61 (1): 15–21. doi:10.1016/S0376-8716(00)00119-8. 

[edit] See also

List of cocaine analogues


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