2,5-dioxovalerate dehydrogenase

From Wikipedia, the free encyclopedia

In enzymology, a 2,5-dioxovalerate dehydrogenase (EC 1.2.1.26) is an enzyme that catalyzes the chemical reaction

2,5-dioxopentanoate + NADP⁺ + H₂O 2-oxoglutarate + NADPH + 2 H⁺

The 3 substrates of this enzyme are 2,5-dioxopentanoate, NADP⁺, and H₂O, whereas its 3 products are 2-oxoglutarate, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2,5-dioxopentanoate:NADP+ 5-oxidoreductase. Other names in common use include 2-oxoglutarate semialdehyde dehydrogenase, and alpha-ketoglutaric semialdehyde dehydrogenase. This enzyme participates in ascorbate and aldarate metabolism.

[edit] References

• IUBMB entry for 1.2.1.26
• BRENDA references for 1.2.1.26 (Recommended.)
• PubMed references for 1.2.1.26
• PubMed Central references for 1.2.1.26
• Google Scholar references for 1.2.1.26
• Adams E and Rosso, G (1967). "alpha-Ketoglutaric semialdehyde dehydrogenase of Pseudomonas Properties of the purified enzyme induced by hydroxyproline and of the glucarate-induced and constitutive enzymes". J. Biol. Chem. 242: 1803–1814. 

[edit] External links

The CAS registry number for this enzyme class is 37250-92-3.

• IUBMB entry for 1.2.1.26

• KEGG entry for 1.2.1.26

• BRENDA entry for 1.2.1.26

• NiceZyme view of 1.2.1.26

• EC2PDB: PDB structures for 1.2.1.26

• PRIAM entry for 1.2.1.26

• PUMA2 entry for 1.2.1.26

• IntEnz: Integrated Enzyme entry for 1.2.1.26

• MetaCyc entry for 1.2.1.26

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047533: 2,5-dioxovalerate dehydrogenase

• AMIGO entry for GO code 0047533: 2,5-dioxovalerate dehydrogenase