2,4-diaminopentanoate dehydrogenase

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In enzymology, a 2,4-diaminopentanoate dehydrogenase (EC 1.4.1.12) is an enzyme that catalyzes the chemical reaction

2,4-diaminopentanoate + H₂O + NAD(P)+ $\rightleftharpoons$ 2-amino-4-oxopentanoate + NH₃ + NAD(P)H + H⁺

The 4 substrates of this enzyme are 2,4-diaminopentanoate, H₂O, NAD⁺, and NADP⁺, whereas its 5 products are 2-amino-4-oxopentanoate, NH₃, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH2 group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2,4-diaminopentanoate:NAD(P)+ oxidoreductase (deaminating). This enzyme is also called 2,4-diaminopentanoic acid C4 dehydrogenase. This enzyme participates in 3 metabolic pathways: lysine degradation, arginine and proline metabolism, and d-arginine and d-ornithine metabolism.

[edit] References

IUBMB entry for 1.4.1.12
BRENDA references for 1.4.1.12 (Recommended.)
PubMed references for 1.4.1.12
PubMed Central references for 1.4.1.12
Google Scholar references for 1.4.1.12
Somack R, Costilow RN (1973). "2,4-diaminopentanoic acid C 4 dehydrogenase. Purification and properties of the protein". J. Biol. Chem. 248: 385–8. PMID 4684685.
Stadtman TC (1973). "Lysine metabolism by clostridia. XIIB 2,4-Diaminohexanoate dehydrogenase (2,4-diaminopentanoate dehydrogenase)". Adv. Enzymol. Relat. Areas Mol. Biol. 38: 441–445.
Tsuda Y, Friedmann HC (1970). "Ornithine metabolism by Clostridium sticklandii. Oxidation of ornithine to 2-amino-4-ketopentanoic acid via 2,4-diaminopentanoic acid; participation of B12 coenzyme, pyridoxal phosphate, and pyridine nucleotide". J. Biol. Chem. 245: 5914–26. PMID 4394942.