2,3-dihydroxyindole 2,3-dioxygenase

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In enzymology, a 2,3-dihydroxyindole 2,3-dioxygenase (EC 1.13.11.23) is an enzyme that catalyzes the chemical reaction

2,3-dihydroxyindole + O₂ anthranilate + CO₂

Thus, the two substrates of this enzyme are 2,3-dihydroxyindole and O₂, whereas its two products are anthranilate and CO₂.

This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O₂ as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O₂. The systematic name of this enzyme class is 2,3-dihydroxyindole:oxygen 2,3-oxidoreductase (decyclizing). This enzyme participates in tryptophan metabolism.

[edit] References

• IUBMB entry for 1.13.11.23
• BRENDA references for 1.13.11.23 (Recommended.)
• PubMed references for 1.13.11.23
• PubMed Central references for 1.13.11.23
• Google Scholar references for 1.13.11.23
• Fujioka M, Wada H (1968). "The bacterial oxidation of indole". Biochim. Biophys. Acta. 158: 70–8. PMID 5652436. 

[edit] External links

The CAS registry number for this enzyme class is 37256-62-5.

• IUBMB entry for 1.13.11.23

• KEGG entry for 1.13.11.23

• BRENDA entry for 1.13.11.23

• NiceZyme view of 1.13.11.23

• EC2PDB: PDB structures for 1.13.11.23

• PRIAM entry for 1.13.11.23

• PUMA2 entry for 1.13.11.23

• IntEnz: Integrated Enzyme entry for 1.13.11.23

• MetaCyc entry for 1.13.11.23

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047528: 2,3-dihydroxyindole 2,3-dioxygenase

• AMIGO entry for GO code 0047528: 2,3-dihydroxyindole 2,3-dioxygenase