2,3-dihydroxy-2,3-dihydro-p-cumate dehydrogenase

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In enzymology, a 2,3-dihydroxy-2,3-dihydro-p-cumate dehydrogenase (EC 1.3.1.58) is an enzyme that catalyzes the chemical reaction

cis-5,6-dihydroxy-4-isopropylcyclohexa-1,3-dienecarboxylate + NAD⁺ 2,3-dihydroxy-p-cumate + NADH + H⁺

Thus, the two substrates of this enzyme are cis-5,6-dihydroxy-4-isopropylcyclohexa-1,3-dienecarboxylate and NAD⁺, whereas its 3 products are 2,3-dihydroxy-p-cumate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is cis-2,3-dihydroxy-2,3-dihydro-p-cumate:NAD+ oxidoreductase. This enzyme participates in biphenyl degradation.

[edit] References

• IUBMB entry for 1.3.1.58
• BRENDA references for 1.3.1.58 (Recommended.)
• PubMed references for 1.3.1.58
• PubMed Central references for 1.3.1.58
• Google Scholar references for 1.3.1.58
• Eaton RW (1996). "p-Cumate catabolic pathway in Pseudomonas putida Fl: cloning and characterization of DNA carrying the cmt operon". J. Bacteriol. 178: 1351–62. PMID 8631713. 

[edit] External links

• IUBMB entry for 1.3.1.58

• KEGG entry for 1.3.1.58

• BRENDA entry for 1.3.1.58

• NiceZyme view of 1.3.1.58

• EC2PDB: PDB structures for 1.3.1.58

• PRIAM entry for 1.3.1.58

• PUMA2 entry for 1.3.1.58

• IntEnz: Integrated Enzyme entry for 1.3.1.58

• MetaCyc entry for 1.3.1.58

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0018511: 2,3-dihydroxy-2,3-dihydro-p-cumate dehydrogenase

• AMIGO entry for GO code 0018511: 2,3-dihydroxy-2,3-dihydro-p-cumate dehydrogenase