2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
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In enzymology, a 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase (EC 1.3.1.28) is an enzyme that catalyzes the chemical reaction
- 2,3-dihydro-2,3-dihydroxybenzoate + NAD+
2,3-dihydroxybenzoate + NADH + H+
Thus, the two substrates of this enzyme are 2,3-dihydro-2,3-dihydroxybenzoate and NAD+, whereas its 3 products are 2,3-dihydroxybenzoate, NADH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2,3-dihydro-2,3-dihydroxybenzoate:NAD+ oxidoreductase. This enzyme is also called 2,3-DHB dehydrogenase. This enzyme participates in biosynthesis of siderophore group nonribosomal and [[]].
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[edit] Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2FWM.
[edit] References
- IUBMB entry for 1.3.1.28
- BRENDA references for 1.3.1.28 (Recommended.)
- PubMed references for 1.3.1.28
- PubMed Central references for 1.3.1.28
- Google Scholar references for 1.3.1.28
- Young IG, Gibson F (1969). "Regulation of the enzymes involved in the biosynthesis of 2,3-dihydroxybenzoic acid in Aerobacter aerogenes and Escherichia coli". Biochim. Biophys. Acta. 177: 401–11. PMID 4306838.
[edit] External links
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- The CAS registry number for this enzyme class is 37250-40-1.
[edit] Gene Ontology (GO) codes
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