17-alpha-hydroxyprogesterone aldolase

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In enzymology, a 17alpha-hydroxyprogesterone aldolase (EC 4.1.2.30) is an enzyme that catalyzes the chemical reaction

17alpha-hydroxyprogesterone 4-androstene-3,17-dione + acetaldehyde

Hence, this enzyme has one substrate, 17alpha-hydroxyprogesterone, and two products, 4-androstene-3,17-dione and acetaldehyde.

This enzyme belongs to the family of lyases, specifically the aldehyde-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 17alpha-hydroxyprogesterone acetaldehyde-lyase (4-androstene-3,17-dione-forming). Other names in common use include C-17/C-20 lyase, and 17alpha-hydroxyprogesterone acetaldehyde-lyase. This enzyme participates in androgen and estrogen metabolism.

[edit] References

• IUBMB entry for 4.1.2.30
• BRENDA references for 4.1.2.30 (Recommended.)
• PubMed references for 4.1.2.30
• PubMed Central references for 4.1.2.30
• Google Scholar references for 4.1.2.30
• Nowotny E, Sananez RD, Nattero G, Yantorno C, Faillaci MG (1974). "Bioconversion of steroids in vitro by testes from autoimmunized rabbits". Hoppe. Seylers. Z. Physiol. Chem. 355: 716–20. PMID 4435747. 

[edit] External links

The CAS registry number for this enzyme class is 62213-24-5.

• IUBMB entry for 4.1.2.30

• KEGG entry for 4.1.2.30

• BRENDA entry for 4.1.2.30

• NiceZyme view of 4.1.2.30

• EC2PDB: PDB structures for 4.1.2.30

• PRIAM entry for 4.1.2.30

• PUMA2 entry for 4.1.2.30

• IntEnz: Integrated Enzyme entry for 4.1.2.30

• MetaCyc entry for 4.1.2.30

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047442: 17-alpha-hydroxyprogesterone aldolase

• AMIGO entry for GO code 0047442: 17-alpha-hydroxyprogesterone aldolase