16-alpha-hydroxysteroid dehydrogenase

From Wikipedia, the free encyclopedia

In enzymology, a 16alpha-hydroxysteroid dehydrogenase (EC 1.1.1.147) is an enzyme that catalyzes the chemical reaction

a 16alpha-hydroxysteroid + NAD(P)+ a 16-oxosteroid + NAD(P)H + H⁺

The 3 substrates of this enzyme are 16alpha-hydroxysteroid, NAD⁺, and NADP⁺, whereas its 4 products are 16-oxosteroid, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 16alpha-hydroxysteroid:NAD(P)+ 16-oxidoreductase. This enzyme is also called 16alpha-hydroxy steroid dehydrogenase.

[edit] References

• IUBMB entry for 1.1.1.147
• BRENDA references for 1.1.1.147 (Recommended.)
• PubMed references for 1.1.1.147
• PubMed Central references for 1.1.1.147
• Google Scholar references for 1.1.1.147
• Meigs RA, Ryan KJ (1966). "16-alpha-hydroxysteroid dehydrogenase of rat kidney. Purification, assay, and properties". J. Biol. Chem. 241: 4011–5. PMID 4380686. 

[edit] External links

The CAS registry number for this enzyme class is 37250-74-1.

• IUBMB entry for 1.1.1.147

• KEGG entry for 1.1.1.147

• BRENDA entry for 1.1.1.147

• NiceZyme view of 1.1.1.147

• EC2PDB: PDB structures for 1.1.1.147

• PRIAM entry for 1.1.1.147

• PUMA2 entry for 1.1.1.147

• IntEnz: Integrated Enzyme entry for 1.1.1.147

• MetaCyc entry for 1.1.1.147

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047005: 16-alpha-hydroxysteroid dehydrogenase

• AMIGO entry for GO code 0047005: 16-alpha-hydroxysteroid dehydrogenase