15-oxoprostaglandin 13-oxidase

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In enzymology, a 15-oxoprostaglandin 13-oxidase (EC 1.3.1.48) is an enzyme that catalyzes the chemical reaction

(5Z)-(15S)-11alpha-hydroxy-9,15-dioxoprostanoate + NAD(P)+ $\rightleftharpoons$ (5Z)-(15S)-11alpha-hydroxy-9,15-dioxoprosta-13-enoate + NAD(P)H + H⁺

The 3 substrates of this enzyme are (5Z)-(15S)-11alpha-hydroxy-9,15-dioxoprostanoate, NAD⁺, and NADP⁺, whereas its 4 products are (5Z)-(15S)-11alpha-hydroxy-9,15-dioxoprosta-13-enoate, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (5Z)-(15S)-11alpha-hydroxy-9,15-dioxoprostanoate:NAD(P)+ Delta13-oxidoreductase. Other names in common use include 15-oxo-Delta13-prostaglandin reductase, Delta13-15-ketoprostaglandin reductase, 15-ketoprostaglandin Delta13-reductase, prostaglandin Delta13-reductase, prostaglandin 13-reductase, and 15-ketoprostaglandin Delta13-reductase.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1V3T, 1V3U, 1V3V, and 2DM6.

[edit] References

IUBMB entry for 1.3.1.48
BRENDA references for 1.3.1.48 (Recommended.)
PubMed references for 1.3.1.48
PubMed Central references for 1.3.1.48
Google Scholar references for 1.3.1.48
Hansen HS (1982). "Purification and assay of 15-ketoprostaglandin delta 13-reductase from bovine lung". Methods. Enzymol. 86: 156–63. PMID 6290839.
Jarabak J (1982). "Isolation and properties of a 15-ketoprostaglandin delta 13-reductase from human placenta". Methods. Enzymol. 86: 163–7. PMID 7132753.