15-hydroxyicosatetraenoate dehydrogenase

From Wikipedia, the free encyclopedia

In enzymology, a 15-hydroxyicosatetraenoate dehydrogenase (EC 1.1.1.232) is an enzyme that catalyzes the chemical reaction

(15S)-15-hydroxy-5,8,11-cis-13-trans-icosatetraenoate + NAD(P)+ 15-oxo-5,8,11-cis-13-trans-icosatetraenoate + NAD(P)H + H⁺

The 3 substrates of this enzyme are (15S)-15-hydroxy-5,8,11-cis-13-trans-icosatetraenoate, NAD⁺, and NADP⁺, whereas its 4 products are 15-oxo-5,8,11-cis-13-trans-icosatetraenoate, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (15S)-15-hydroxy-5,8,11-cis-13-trans-icosatetraenoate:NAD(P)+ 15-oxidoreductase. This enzyme is also called 15-hydroxyeicosatetraenoate dehydrogenase. This enzyme participates in arachidonic acid metabolism.

[edit] References

• IUBMB entry for 1.1.1.232
• BRENDA references for 1.1.1.232 (Recommended.)
• PubMed references for 1.1.1.232
• PubMed Central references for 1.1.1.232
• Google Scholar references for 1.1.1.232
• Sok DE, Kang JB, Shin HD (1988). "15-Hydroxyeicosatetraenoic acid dehydrogenase activity in microsomal fraction of mouse liver homogenate". Biochem. Biophys. Res. Commun. 156: 524–9. PMID 3052453. 

[edit] External links

The CAS registry number for this enzyme class is 117910-46-0.

• IUBMB entry for 1.1.1.232

• KEGG entry for 1.1.1.232

• BRENDA entry for 1.1.1.232

• NiceZyme view of 1.1.1.232

• EC2PDB: PDB structures for 1.1.1.232

• PRIAM entry for 1.1.1.232

• PUMA2 entry for 1.1.1.232

• IntEnz: Integrated Enzyme entry for 1.1.1.232

• MetaCyc entry for 1.1.1.232

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047034: 15-hydroxyicosatetraenoate dehydrogenase

• AMIGO entry for GO code 0047034: 15-hydroxyicosatetraenoate dehydrogenase