12-oxophytodienoate reductase

From Wikipedia, the free encyclopedia

In enzymology, a 12-oxophytodienoate reductase (EC 1.3.1.42) is an enzyme that catalyzes the chemical reaction

8-[(1R,2R)-3-oxo-2-{(Z)-pent-2-enyl}cyclopentyl]octanoate + NADP⁺ (15Z)-12-oxophyto-10,15-dienoate + NADPH + H⁺

Thus, the two substrates of this enzyme are [[8-[(1R,2R)-3-oxo-2-{(Z)-pent-2-enyl}cyclopentyl]octanoate]] and NADP⁺, whereas its 3 products are (15Z)-12-oxophyto-10,15-dienoate, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 8-[(1R,2R)-3-oxo-2-{(Z)-pent-2-enyl}cyclopentyl]octanoate:NADP+ 4-oxidoreductase. This enzyme is also called 12-oxo-phytodienoic acid reductase.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 10 structures have been solved for this class of enzymes, with PDB accession codes 1ICP, 1ICQ, 1ICS, 1Q45, 2G5W, 2HS6, 2HS8, 2HSA, 2Q3O, and 2Q3R.

[edit] References

• IUBMB entry for 1.3.1.42
• BRENDA references for 1.3.1.42 (Recommended.)
• PubMed references for 1.3.1.42
• PubMed Central references for 1.3.1.42
• Google Scholar references for 1.3.1.42
• Vick BA and Zimmerman DC (1986). "Characterization of 12-oxo-phytodienoic acid reductase in corn - the jasmonic acid pathway". Plant Physiol. 80: 202–205. 

[edit] External links

The CAS registry number for this enzyme class is 101150-03-2.

• IUBMB entry for 1.3.1.42

• KEGG entry for 1.3.1.42

• BRENDA entry for 1.3.1.42

• NiceZyme view of 1.3.1.42

• EC2PDB: PDB structures for 1.3.1.42

• PRIAM entry for 1.3.1.42

• PUMA2 entry for 1.3.1.42

• IntEnz: Integrated Enzyme entry for 1.3.1.42

• MetaCyc entry for 1.3.1.42

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0016629: 12-oxophytodienoate reductase

• AMIGO entry for GO code 0016629: 12-oxophytodienoate reductase