1-pyrroline-4-hydroxy-2-carboxylate deaminase

From Wikipedia, the free encyclopedia

In enzymology, a 1-pyrroline-4-hydroxy-2-carboxylate deaminase (EC 3.5.4.22) is an enzyme that catalyzes the chemical reaction

1-pyrroline-4-hydroxy-2-carboxylate + H₂O 2,5-dioxopentanoate + NH₃

Thus, the two substrates of this enzyme are 1-pyrroline-4-hydroxy-2-carboxylate and H₂O, whereas its two products are 2,5-dioxopentanoate and NH₃.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is 1-pyrroline-4-hydroxy-2-carboxylate aminohydrolase (decyclizing). This enzyme is also called HPC deaminase. This enzyme participates in arginine and proline metabolism.

[edit] References

• IUBMB entry for 3.5.4.22
• BRENDA references for 3.5.4.22 (Recommended.)
• PubMed references for 3.5.4.22
• PubMed Central references for 3.5.4.22
• Google Scholar references for 3.5.4.22
• Singh RMM and Adams E (1965). "Enzymatic deamination of Delta1-pyrroline-4-hydroxy-2-carboxylate to 2,5-dioxovalerate (alpha-ketoglutaric semialdehyde)". J. Biol. Chem. 240: 4344–4351. 
• Singh RMM and Adams E (1965). "Isolation and identification of 2,5-dioxovalerate, an intermediate in the bacterial oxidation of hydroxyproline". J. Biol. Chem. 240: 4352–4356. 

[edit] External links

The CAS registry number for this enzyme class is 9054-77-7.

• IUBMB entry for 3.5.4.22

• KEGG entry for 3.5.4.22

• BRENDA entry for 3.5.4.22

• NiceZyme view of 3.5.4.22

• EC2PDB: PDB structures for 3.5.4.22

• PRIAM entry for 3.5.4.22

• PUMA2 entry for 3.5.4.22

• IntEnz: Integrated Enzyme entry for 3.5.4.22

• MetaCyc entry for 3.5.4.22

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047425: 1-pyrroline-4-hydroxy-2-carboxylate deaminase

• AMIGO entry for GO code 0047425: 1-pyrroline-4-hydroxy-2-carboxylate deaminase