1-phosphofructokinase

From Wikipedia, the free encyclopedia

In enzymology, a 1-phosphofructokinase (EC 2.7.1.56) is an enzyme that catalyzes the chemical reaction

ATP + D-fructose 1-phosphate $\rightleftharpoons$ ADP + D-fructose 1,6-bisphosphate

Thus, the two substrates of this enzyme are ATP and D-fructose 1-phosphate, whereas its two products are ADP and D-fructose 1,6-bisphosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:D-fructose-phosphate 6-phosphotransferase. Other names in common use include fructose-1-phosphate kinase, 1-phosphofructokinase (phosphorylating), D-fructose-1-phosphate kinase, fructose 1-phosphate kinase, and phosphofructokinase 1. This enzyme participates in fructose and mannose metabolism.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2JG5.

[edit] References

IUBMB entry for 2.7.1.56
BRENDA references for 2.7.1.56 (Recommended.)
PubMed references for 2.7.1.56
PubMed Central references for 2.7.1.56
Google Scholar references for 2.7.1.56
Reeves RE, Warren LG, Hsu DS (1966). "1-Phosphofructokinase from an anaerobe". J. Biol. Chem. 241: 1257–61. PMID 4222878.
Sapico V, Anderson RL (1969). "D-fructose 1-phosphate kinase and D-fructose 6-phosphate kinase from Aerobacter aerogenes. A comparative study of regulatory properties". J. Biol. Chem. 244: 6280–8. PMID 4242639.