1-hydroxy-2-naphthoate 1,2-dioxygenase

From Wikipedia, the free encyclopedia

In enzymology, a 1-hydroxy-2-naphthoate 1,2-dioxygenase (EC 1.13.11.38) is an enzyme that catalyzes the chemical reaction

1-hydroxy-2-naphthoate + O₂ (3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate

Thus, the two substrates of this enzyme are 1-hydroxy-2-naphthoate and O₂, whereas its product is (3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate.

This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O₂ as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O₂. The systematic name of this enzyme class is 1-hydroxy-2-naphthoate:oxygen 1,2-oxidoreductase (decyclizing). Other names in common use include 1-hydroxy-2-naphthoate dioxygenase, 1-hydroxy-2-naphthoate-degrading enzyme, and 1-hydroxy-2-naphthoic acid dioxygenase. This enzyme participates in naphthalene and anthracene degradation. It employs one cofactor, iron.

[edit] References

• IUBMB entry for 1.13.11.38
• BRENDA references for 1.13.11.38 (Recommended.)
• PubMed references for 1.13.11.38
• PubMed Central references for 1.13.11.38
• Google Scholar references for 1.13.11.38
• Barnsley EA (1983). "Phthalate pathway of phenanthrene metabolism: formation of 2'-carboxybenzalpyruvate". J. Bacteriol. 154: 113–7. PMID 6833175. 

[edit] External links

The CAS registry number for this enzyme class is 85941-64-6.

• IUBMB entry for 1.13.11.38

• KEGG entry for 1.13.11.38

• BRENDA entry for 1.13.11.38

• NiceZyme view of 1.13.11.38

• EC2PDB: PDB structures for 1.13.11.38

• PRIAM entry for 1.13.11.38

• PUMA2 entry for 1.13.11.38

• IntEnz: Integrated Enzyme entry for 1.13.11.38

• MetaCyc entry for 1.13.11.38

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0018582: 1-hydroxy-2-naphthoate 1,2-dioxygenase

• AMIGO entry for GO code 0018582: 1-hydroxy-2-naphthoate 1,2-dioxygenase