1-aminocyclopropane-1-carboxylate synthase

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In enzymology, a 1-aminocyclopropane-1-carboxylate synthase (EC 4.4.1.14) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine $\rightleftharpoons$ 1-aminocyclopropane-1-carboxylate + methylthioadenosine

Hence, this enzyme has one substrate, S-adenosyl-L-methionine, and two products, 1-aminocyclopropane-1-carboxylate and methylthioadenosine.

This enzyme belongs to the family of lyases, specifically carbon-sulfur lyases. The systematic name of this enzyme class is S-adenosyl-L-methionine methylthioadenosine-lyase (1-aminocyclopropane-1-carboxylate-forming). Other names in common use include 1-aminocyclopropanecarboxylate synthase, 1-aminocyclopropane-1-carboxylic acid synthase, 1-aminocyclopropane-1-carboxylate synthetase, aminocyclopropanecarboxylic acid synthase, aminocyclopropanecarboxylate synthase, ACC synthase, and S-adenosyl-L-methionine methylthioadenosine-lyase. This enzyme participates in propanoate metabolism. It employs one cofactor, pyridoxal phosphate.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes 1B8G, 1IAX, 1IAY, 1M4N, 1M7Y, and 1YNU.

[edit] References

IUBMB entry for 4.4.1.14
BRENDA references for 4.4.1.14 (Recommended.)
PubMed references for 4.4.1.14
PubMed Central references for 4.4.1.14
Google Scholar references for 4.4.1.14
Boller T, Herner RC and Kende H (1979). "Assay for and enzymatic formation of an ethylene precursor, 1-aminocyclopropane-1-carboxylic acid". Planta 145: 293–303. doi:10.1007/BF00454455.
Yu YB, Adams DO, Yang SF (1979). "1-Aminocyclopropanecarboxylate synthase, a key enzyme in ethylene biosynthesis". Arch. Biochem. Biophys. 198: 280–6. doi:10.1016/0003-9861(79)90420-X. PMID 507845.