1-alkylglycerophosphocholine O-acyltransferase

From Wikipedia, the free encyclopedia

In enzymology, a 1-alkylglycerophosphocholine O-acyltransferase (EC 2.3.1.63) is an enzyme that catalyzes the chemical reaction

acyl-CoA + 1-alkyl-sn-glycero-3-phosphocholine CoA + 2-acyl-1-alkyl-sn-glycero-3-phosphocholine

Thus, the two substrates of this enzyme are acyl-CoA and 1-alkyl-sn-glycero-3-phosphocholine, whereas its two products are CoA and 2-acyl-1-alkyl-sn-glycero-3-phosphocholine.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl-CoA:1-alkyl-sn-glycero-3-phosphocholine O-acyltransferase. This enzyme participates in ether lipid metabolism.

[edit] References

• IUBMB entry for 2.3.1.63
• BRENDA references for 2.3.1.63 (Recommended.)
• PubMed references for 2.3.1.63
• PubMed Central references for 2.3.1.63
• Google Scholar references for 2.3.1.63
• Waku K, Nakazawa Y (Tokyo). "Acyltransferase activity to 1-O-alkyl-glycero-3-phosphorylcholine in sarcoplasmic reticulum". J. Biochem.: 459–66. PMID 5488773. 
• Waku K, Nakazawa Y (Tokyo). "Acyltransferae activity to 1-acyl-, 1-O-alkenyl-, and 1-O-alkyl-glycero-3-phosphorylcholine in Ehrlich ascites tumor cells". J. Biochem.: 495–7. PMID 4644313. 

[edit] External links

The CAS registry number for this enzyme class is 58693-63-3.

• IUBMB entry for 2.3.1.63

• KEGG entry for 2.3.1.63

• BRENDA entry for 2.3.1.63

• NiceZyme view of 2.3.1.63

• EC2PDB: PDB structures for 2.3.1.63

• PRIAM entry for 2.3.1.63

• PUMA2 entry for 2.3.1.63

• IntEnz: Integrated Enzyme entry for 2.3.1.63

• MetaCyc entry for 2.3.1.63

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047191: 1-alkylglycerophosphocholine O-acyltransferase

• AMIGO entry for GO code 0047191: 1-alkylglycerophosphocholine O-acyltransferase