1-alkylglycerophosphocholine O-acetyltransferase

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In enzymology, a 1-alkylglycerophosphocholine O-acetyltransferase (EC 2.3.1.67) is an enzyme that catalyzes the chemical reaction

acetyl-CoA + 1-alkyl-sn-glycero-3-phosphocholine CoA + 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine

Thus, the two substrates of this enzyme are acetyl-CoA and 1-alkyl-sn-glycero-3-phosphocholine, whereas its two products are CoA and 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:1-alkyl-sn-glycero-3-phosphocholine 2-O-acetyltransferase. Other names in common use include acetyl-CoA:1-alkyl-2-lyso-sn-glycero-3-phosphocholine, 2-O-acetyltransferase, acetyl-CoA:lyso-PAF acetyltransferase, 1-alkyl-2-lysolecithin acetyltransferase, acyl-CoA:1-alkyl-sn-glycero-3-phosphocholine acyltransferase, blood platelet-activating factor acetyltransferase, lyso-GPC:acetyl CoA acetyltransferase, lyso-platelet activating factor:acetyl-CoA acetyltransferase, lysoPAF:acetyl CoA acetyltransferase, PAF acetyltransferase, platelet-activating factor acylhydrolase, platelet-activating factor-synthesizing enzyme, 1-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase, and lyso-platelet-activating factor:acetyl-CoA acetyltransferase. This enzyme participates in ether lipid metabolism.

[edit] References

• IUBMB entry for 2.3.1.67
• BRENDA references for 2.3.1.67 (Recommended.)
• PubMed references for 2.3.1.67
• PubMed Central references for 2.3.1.67
• Google Scholar references for 2.3.1.67
• Wykle RL, Malone B, Snyder F (1980). "Enzymatic synthesis of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine, a hypotensive and platelet-aggregating lipid". J. Biol. Chem. 255: 10256–60. PMID 7430122. 

[edit] External links

The CAS registry number for this enzyme class is 76773-96-1.

• IUBMB entry for 2.3.1.67

• KEGG entry for 2.3.1.67

• BRENDA entry for 2.3.1.67

• NiceZyme view of 2.3.1.67

• EC2PDB: PDB structures for 2.3.1.67

• PRIAM entry for 2.3.1.67

• PUMA2 entry for 2.3.1.67

• IntEnz: Integrated Enzyme entry for 2.3.1.67

• MetaCyc entry for 2.3.1.67

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047192: 1-alkylglycerophosphocholine O-acetyltransferase

• AMIGO entry for GO code 0047192: 1-alkylglycerophosphocholine O-acetyltransferase