1-alkyl-2-acetylglycerol O-acyltransferase

From Wikipedia, the free encyclopedia

In enzymology, a 1-alkyl-2-acetylglycerol O-acyltransferase (EC 2.3.1.125) is an enzyme that catalyzes the chemical reaction

acyl-CoA + 1-O-alkyl-2-acetyl-sn-glycerol CoA + 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol

Thus, the two substrates of this enzyme are acyl-CoA and 1-O-alkyl-2-acetyl-sn-glycerol, whereas its two products are CoA and 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl-CoA:1-O-alkyl-2-acetyl-sn-glycerol O-acyltransferase. This enzyme is also called 1-hexadecyl-2-acetylglycerol acyltransferase. This enzyme participates in ether lipid metabolism.

[edit] References

• IUBMB entry for 2.3.1.125
• BRENDA references for 2.3.1.125 (Recommended.)
• PubMed references for 2.3.1.125
• PubMed Central references for 2.3.1.125
• Google Scholar references for 2.3.1.125
• Kawasaki T, Snyder F (1988). "Synthesis of a novel acetylated neutral lipid related to platelet-activating factor by acyl-CoA:1-O-alkyl-2-acetyl-sn-glycerol acyltransferase in HL-60 cells". J. Biol. Chem. 263: 2593–6. PMID 3422635. 

[edit] External links

The CAS registry number for this enzyme class is 114704-90-4.

• IUBMB entry for 2.3.1.125

• KEGG entry for 2.3.1.125

• BRENDA entry for 2.3.1.125

• NiceZyme view of 2.3.1.125

• EC2PDB: PDB structures for 2.3.1.125

• PRIAM entry for 2.3.1.125

• PUMA2 entry for 2.3.1.125

• IntEnz: Integrated Enzyme entry for 2.3.1.125

• MetaCyc entry for 2.3.1.125

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047167: 1-alkyl-2-acetylglycerol O-acyltransferase

• AMIGO entry for GO code 0047167: 1-alkyl-2-acetylglycerol O-acyltransferase