1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase

From Wikipedia, the free encyclopedia

In enzymology, a 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (EC 1.3.1.25) is an enzyme that catalyzes the chemical reaction

(1R,6R)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate + NAD⁺ catechol + CO₂ + NADH + H⁺

Thus, the two substrates of this enzyme are (1R,6R)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate and NAD⁺, whereas its 4 products are catechol, CO₂, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (1R,6R)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate:NAD+ oxidoreductase (decarboxylating). Other names in common use include 3,5-cyclohexadiene-1,2-diol-1-carboxylate dehydrogenase, 3,5-cyclohexadiene-1,2-diol-1-carboxylic acid dehydrogenase, dihydrodihydroxybenzoate dehydrogenase, DHBDH, cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate dehydrogenase, 2-hydro-1,2-dihydroxybenzoate dehydrogenase, cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate:NAD+, oxidoreductase, and dihydrodihydroxybenzoate dehydrogenase. This enzyme participates in benzoate degradation via hydroxylation and benzoate degradation via coa ligation.

[edit] References

• IUBMB entry for 1.3.1.25
• BRENDA references for 1.3.1.25 (Recommended.)
• PubMed references for 1.3.1.25
• PubMed Central references for 1.3.1.25
• Google Scholar references for 1.3.1.25
• Reiner AM (1972). "Metabolism of aromatic compounds in bacteria. Purification and properties of the catechol-forming enzyme, 3,5-cyclohexadiene-1,2-diol-1-carboxylic acid (NAD + ) oxidoreductase (decarboxylating)". J. Biol. Chem. 247: 4960–5. PMID 4341530. 
• Neidle E, Hartnett C, Ornston LN, Bairoch A, Rekik M, Harayama S (1992). "cis-diol dehydrogenases encoded by the TOL pWW0 plasmid xylL gene and the Acinetobacter calcoaceticus chromosomal benD gene are members of the short-chain alcohol dehydrogenase superfamily". Eur. J. Biochem. 204: 113–20. doi:10.1111/j.1432-1033.1992.tb16612.x. PMID 1740120. 

[edit] External links

The CAS registry number for this enzyme class is 60496-16-4.

• IUBMB entry for 1.3.1.25

• KEGG entry for 1.3.1.25

• BRENDA entry for 1.3.1.25

• NiceZyme view of 1.3.1.25

• EC2PDB: PDB structures for 1.3.1.25

• PRIAM entry for 1.3.1.25

• PUMA2 entry for 1.3.1.25

• IntEnz: Integrated Enzyme entry for 1.3.1.25

• MetaCyc entry for 1.3.1.25

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047116: 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase

• AMIGO entry for GO code 0047116: 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase