1,5-anhydro-D-fructose reductase

From Wikipedia, the free encyclopedia

In enzymology, a 1,5-anhydro-D-fructose reductase (EC 1.1.1.263) is an enzyme that catalyzes the chemical reaction

1,5-anhydro-D-glucitol + NADP⁺ 1,5-anhydro-D-fructose + NADPH + H⁺

Thus, the two substrates of this enzyme are 1,5-anhydro-D-glucitol and NADP⁺, whereas its 3 products are 1,5-anhydro-D-fructose, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 1,5-anhydro-D-glucitol:NADP+ oxidoreductase.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2GLX.

[edit] References

• IUBMB entry for 1.1.1.263
• BRENDA references for 1.1.1.263 (Recommended.)
• PubMed references for 1.1.1.263
• PubMed Central references for 1.1.1.263
• Google Scholar references for 1.1.1.263
• Sakuma M, Kametani S and Akanuma H (Tokyo). "Purification and some properties of a hepatic NADPH-dependent reductase that specifically acts on 1,5-anhydro-D-fructose". J. Biochem.: 189–193. 

[edit] External links

• IUBMB entry for 1.1.1.263

• KEGG entry for 1.1.1.263

• BRENDA entry for 1.1.1.263

• NiceZyme view of 1.1.1.263

• EC2PDB: PDB structures for 1.1.1.263

• PRIAM entry for 1.1.1.263

• PUMA2 entry for 1.1.1.263

• IntEnz: Integrated Enzyme entry for 1.1.1.263

• MetaCyc entry for 1.1.1.263

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050571: 1,5-anhydro-D-fructose reductase

• AMIGO entry for GO code 0050571: 1,5-anhydro-D-fructose reductase