1,3-propanediol dehydrogenase

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In enzymology, a 1,3-propanediol dehydrogenase (EC 1.1.1.202) is an enzyme that catalyzes the chemical reaction

propane-1,3-diol + NAD⁺ $\rightleftharpoons$ 3-hydroxypropanal + NADH + H⁺

Thus, the two substrates of this enzyme are propane-1,3-diol and NAD⁺, whereas its 3 products are 3-hydroxypropanal, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is propane-1,3-diol:NAD+ 1-oxidoreductase. Other names in common use include 3-hydroxypropionaldehyde reductase, 1,3-PD:NAD+ oxidoreductase, 1,3-propanediol:NAD+ oxidoreductase, and 1,3-propanediol dehydrogenase. This enzyme participates in ether lipid metabolism as a step in glycerolipid biosynthesis.

[edit] References

IUBMB entry for 1.1.1.202
BRENDA references for 1.1.1.202 (Recommended.)
PubMed references for 1.1.1.202
PubMed Central references for 1.1.1.202
Google Scholar references for 1.1.1.202
ABELES RH, BROWNSTEIN AM, RANDLES CH (1960). "beta-Hydroxypropionaldehyde, an intermediate in the formation of 1,3-propanediol by Aerobacter aerogenes". Biochim. Biophys. Acta. 41: 530–1. PMID 13791444.
Forage RG, Foster MA (1982). "Glycerol fermentation in Klebsiella pneumoniae: functions of the coenzyme B12-dependent glycerol and diol dehydratases". J. Bacteriol. 149: 413–9. PMID 7035429.