1,3-alpha-L-fucosidase

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In enzymology, a 1,3-alpha-L-fucosidase (EC 3.2.1.111) is an enzyme that catalyzes the chemical reaction of cleaving the 1,3-linkages between alpha-L-fucose and N-acetylglucosamine residues in glycoproteins.

This enzyme belongs to the family of hydrolases, specifically those glycosidases that hydrolyse O- and S-glycosyl compounds. The systematic name of this enzyme class is 3-alpha-L-fucosyl-N-acetylglucosaminyl-glycoprotein fucohydrolase. This enzyme is also called almond emulsin fucosidase I. This enzyme participates in the degradation of glycan structures.

[edit] References

• IUBMB entry for 3.2.1.111
• BRENDA references for 3.2.1.111 (Recommended.)
• PubMed references for 3.2.1.111
• PubMed Central references for 3.2.1.111
• Google Scholar references for 3.2.1.111
• Imber MJ, Glasgow LR, Pizzo SV (1982). "Purification of an almond emulsin fucosidase on Cibacron blue-sepharose and demonstration of its activity toward fucose-containing glycoproteins". J. Biol. Chem. 257: 8205–10. PMID 7085666. 
• Ogata-Arakawa M, Muramatsu T, Kobata A (1977). "alpha-L-fucosidases from almond emulsin: characterization of the two enzymes with different specificities". Arch. Biochem. Biophys. 181: 353–8. doi:10.1016/0003-9861(77)90514-8. PMID 18111. 
• Yoshima H, Takasaki S, Ito-Mega S, Kobata A (1979). "Purification of almond emulsin alpha-L-fucosidase I by affinity chromatography". Arch. Biochem. Biophys. 194: 394–8. doi:10.1016/0003-9861(79)90632-5. PMID 443810. 

[edit] External links

The CAS registry number for this enzyme class is 83061-50-1.

• IUBMB entry for 3.2.1.111

• KEGG entry for 3.2.1.111

• BRENDA entry for 3.2.1.111

• NiceZyme view of 3.2.1.111

• EC2PDB: PDB structures for 3.2.1.111

• PRIAM entry for 3.2.1.111

• PUMA2 entry for 3.2.1.111

• IntEnz: Integrated Enzyme entry for 3.2.1.111

• MetaCyc entry for 3.2.1.111

• Atomic-resolution structures of enzymes belonging to this class