1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate dehydrogenase

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In enzymology, a 1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate dehydrogenase (EC 1.3.1.68) is an enzyme that catalyzes the chemical reaction

1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate + NAD⁺ 3-methylcatechol + NADH + CO₂

Thus, the two substrates of this enzyme are 1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate and NAD⁺, whereas its 3 products are 3-methylcatechol, NADH, and CO₂.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate:NAD+ oxidoreductase (decarboxylating). This enzyme participates in toluene and xylene degradation.

[edit] References

• IUBMB entry for 1.3.1.68
• BRENDA references for 1.3.1.68 (Recommended.)
• PubMed references for 1.3.1.68
• PubMed Central references for 1.3.1.68
• Google Scholar references for 1.3.1.68
• Higson FK, Focht DD (1992). "Degradation of 2-methylbenzoic acid by Pseudomonas cepacia MB2". Appl. Environ. Microbiol. 58: 194–200. PMID 1371658. 

[edit] External links

• IUBMB entry for 1.3.1.68

• KEGG entry for 1.3.1.68

• BRENDA entry for 1.3.1.68

• NiceZyme view of 1.3.1.68

• EC2PDB: PDB structures for 1.3.1.68

• PRIAM entry for 1.3.1.68

• PUMA2 entry for 1.3.1.68

• IntEnz: Integrated Enzyme entry for 1.3.1.68

• MetaCyc entry for 1.3.1.68

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0018521: 1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate dehydrogenase

• AMIGO entry for GO code 0018521: 1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate dehydrogenase