1,2-dihydrovomilenine reductase

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In enzymology, a 1,2-dihydrovomilenine reductase (EC 1.3.1.73) is an enzyme that catalyzes the chemical reaction

17-O-acetylnorajmaline + NADP⁺ 1,2-dihydrovomilenine + NADPH + H⁺

Thus, the two substrates of this enzyme are 17-O-acetylnorajmaline and NADP⁺, whereas its 3 products are 1,2-dihydrovomilenine, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 17-O-acetylnorajmaline:NADP+ oxidoreductase. This enzyme participates in indole and ipecac alkaloid biosynthesis.

[edit] References

• IUBMB entry for 1.3.1.73
• BRENDA references for 1.3.1.73 (Recommended.)
• PubMed references for 1.3.1.73
• PubMed Central references for 1.3.1.73
• Google Scholar references for 1.3.1.73
• Gao S, von Schumann G, Stockigt J (2002). "A newly-detected reductase from Rauvolfia closes a gap in the biosynthesis of the antiarrhythmic alkaloid ajmaline". Planta. Med. 68: 906–11. doi:10.1055/s-2002-34935. PMID 12391554. 

[edit] External links

• IUBMB entry for 1.3.1.73

• KEGG entry for 1.3.1.73

• BRENDA entry for 1.3.1.73

• NiceZyme view of 1.3.1.73

• EC2PDB: PDB structures for 1.3.1.73

• PRIAM entry for 1.3.1.73

• PUMA2 entry for 1.3.1.73

• IntEnz: Integrated Enzyme entry for 1.3.1.73

• MetaCyc entry for 1.3.1.73

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050615: 1,2-dihydrovomilenine reductase

• AMIGO entry for GO code 0050615: 1,2-dihydrovomilenine reductase