1,2-dehydroreticulinium reductase (NADPH)

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In enzymology, a 1,2-dehydroreticulinium reductase (NADPH) (EC 1.5.1.27) is an enzyme that catalyzes the chemical reaction

(R)-reticuline + NADP⁺ 1,2-dehydroreticulinium + NADPH + H⁺

Thus, the two substrates of this enzyme are (R)-reticuline and NADP⁺, whereas its 3 products are 1,2-dehydroreticulinium, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-reticuline:NADP+ oxidoreductase. This enzyme is also called 1,2-dehydroreticulinium ion reductase. This enzyme participates in alkaloid biosynthesis i.

[edit] References

• IUBMB entry for 1.5.1.27
• BRENDA references for 1.5.1.27 (Recommended.)
• PubMed references for 1.5.1.27
• PubMed Central references for 1.5.1.27
• Google Scholar references for 1.5.1.27
• De-Eknamkul W and Zenk MH (1992). "Purification and properties of 1,2-dehydroreticulinium reductase from Papaver somniferum seedlings". Phytochemistry 31: 813–821. 

[edit] External links

The CAS registry number for this enzyme class is 130590-58-8.

• IUBMB entry for 1.5.1.27

• KEGG entry for 1.5.1.27

• BRENDA entry for 1.5.1.27

• NiceZyme view of 1.5.1.27

• EC2PDB: PDB structures for 1.5.1.27

• PRIAM entry for 1.5.1.27

• PUMA2 entry for 1.5.1.27

• IntEnz: Integrated Enzyme entry for 1.5.1.27

• MetaCyc entry for 1.5.1.27

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047128: 1,2-dehydroreticulinium reductase (NADPH)

• AMIGO entry for GO code 0047128: 1,2-dehydroreticulinium reductase (NADPH)