1,2-alpha-L-fucosidase

From Wikipedia, the free encyclopedia

In enzymology, a 1,2-alpha-L-fucosidase (EC 3.2.1.63) is an enzyme that catalyzes the chemical reaction

methyl-2-alpha-L-fucopyranosyl-beta-D-galactoside + H₂O $\rightleftharpoons$ L-fucose + methyl beta-D-galactoside

Thus, the two substrates of this enzyme are methyl-2-alpha-L-fucopyranosyl-beta-D-galactoside and H₂O, whereas its two products are L-fucose and methyl beta-D-galactoside.

This enzyme belongs to the family of hydrolases, specifically those glycosidases that hydrolyse O- and S-glycosyl compounds. The systematic name of this enzyme class is 2-alpha-L-fucopyranosyl-beta-D-galactoside fucohydrolase. Other names in common use include almond emulsin fucosidase, and alpha-(1->2)-L-fucosidase.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 2EAB, 2EAC, 2EAD, and 2EAE.

[edit] References

IUBMB entry for 3.2.1.63
BRENDA references for 3.2.1.63 (Recommended.)
PubMed references for 3.2.1.63
PubMed Central references for 3.2.1.63
Google Scholar references for 3.2.1.63
Bahl OP (1970). "Glycosidases of aspergillus niger. II. Purification and general properties of 1,2-alpha-L-fucosidase". J. Biol. Chem. 245: 299–304. PMID 5460888.
Ogata-Arakawa M, Muramatsu T, Kobata A (1977). "alpha-L-fucosidases from almond emulsin: characterization of the two enzymes with different specificities". Arch. Biochem. Biophys. 181: 353–8. PMID 18111.
Reglero A, Cabezas JA (1976). "Glycosidases of molluscs. Purification and properties of alpha-L-fucosidase from Chamelea gallina L". Eur. J. Biochem. 66: 379–87. PMID 7458.